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2012 Petit Institute Distinguished Lecture
"Biomaterials to Program Cells in situ"
David J. Mooney, PhD
Wyss Institute for Biologically Inspired Engineering
There are hundreds of clinical trials of cell therapy currently underway, but simple cell infusions lead to large-scale cell death, little control over cell fate, and a typically poor clinical outcome. We propose biomaterials to first serve as cell carriers or attractors of host cell populations, and then serve to program the cells in vivo and ultimately disperse the cells to participate in regeneration or immunotherapy.
David Mooney is the Robert P. Pinkas Family Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences (SEAS) and a Core Faculty Member at the Wyss Institute for Biologically Inspired Engineering at Harvard. Mooney earned his PhD in Chemical Engineering at the Massachusetts Institute of Technology and B.S. in Chemical Engineering at the University of Wisconsin, Madison. He designs and synthesizes new biomaterials that regulate the gene expression of interacting cells for a variety of tissue engineering and drug delivery projects. Current projects conducted in his lab focus on therapeutic angiogenesis, regeneration of musculoskeletal tissues, and cancer therapies.
Mooney also plays an active role in the major biomedical and chemical engineering professional societies, serves as an editorial adviser to several journals and publishers, organizes and chairs leading conferences and symposia, and participates on several industry advisory boards.
Lunch reception to follow